The episode

An hour with the baldest hair professor in the Netherlands

Prof. dr. Sherief Janmohamed is dermatoloog en professor. Als de Nederlandse media een haarexpert nodig hebben, bellen ze hem. Meer dan zestig wetenschappelijke publicaties, medeauteur van medische boeken, betrokken bij de opleiding van dermatologen aan de Universiteit van Brussel. En hij is zelf kaal.

Hereditary baldness eventually affects eighty percent of men. In this episode: what really causes it, which treatments do something and which are overrated, what you can expect from a treatment, and why most men find out too late.

Prof. dr. Janmohamed as a hair expert on

All questions

35 chapters

Over an hour, in 35 chapters. Click a question and the video jumps to that moment.

Start treatment
Prof. dr. Sherief Janmohamed, dermatologist

About the guest

Prof. dr. Sherief Janmohamed

Dermatologist · professor · trichologie-adviseur

professor en dermatoloog aan de Universiteit van Brussel, met meer dan zestig wetenschappelijke publicaties en medeauteur van medische boeken. Bij Kádeso Labs beoordeelt hij elke aanvraag persoonlijk.

BIG number 39066055201

Quoted and interviewed by

This episode is general information about hair loss and not personal medical advice. Unsure about your own situation? Discuss it with a doctor.

First, know where you stand

You start with the online hair check, three minutes. Prof. dr. Janmohamed reviews your request personally and decides whether a treatment is suitable.

Start treatment

What does the research say?

Choose a topic. The questions appear below it, and within each answer you can click through for the details and the study behind it. Every claim has a source from PubMed. Everything below is explanation, not medical advice.

Minoxidil
What is minoxidil and how does it work?

Minoxidil is a substance that can stimulate hair growth. It works differently from finasteride: not through hormones, but by acting on the hair growth cycle itself. Click through for the two parts of that story.

What happens to the hair growth cycle?

According to the scientific literature, minoxidil shortens the resting phase (telogen) of the hair and moves hair follicles into the growth phase (anagen) earlier, where the growth phase can last longer and hair follicles can become larger.

Source: Messenger & Rundegren, Br J Dermatol 2004 - PubMed 14996087

Why was minoxidil discovered for hair?

Minoxidil was originally developed as a treatment for high blood pressure. During that use it was noticed that it promoted hair growth, after which it was researched further as a hair treatment. It's a well-known example of a medicine that found a second use alongside its original purpose.

Source: Messenger & Rundegren, Br J Dermatol 2004 - PubMed 14996087

How well does topical minoxidil work in research?

In a randomised study of 393 men, a 5% solution on the scalp gave more hair growth than a 2% solution and than placebo, with a visible effect sooner. The higher concentration did cause local irritation or itching slightly more often. Results vary per person.

Source: Olsen et al., J Am Acad Dermatol 2002 - PubMed 12196747

Topical or as a tablet, does that make a difference?

Minoxidil exists both as a form for the scalp and as a tablet. Research compares both routes; the topical form works locally on the scalp, while a tablet works throughout the whole body via the blood. Which form is suitable is a medical decision the doctor makes.

Source: RCT oral versus topical minoxidil, JAMA Dermatol 2024 - PubMed 38598226

Finasteride
What is finasteride and how does it work?

Finasteride acts on the formation of DHT, the hormone linked to hereditary hair loss. Click open the two concepts.

What is DHT?

DHT (dihydrotestosterone) is a hormone the body makes itself. In men with a hereditary predisposition, the hair follicles are sensitive to it, so the hair gets thinner and the hairline recedes.

Source: 5-alpha-reductase inhibitors, StatPearls (NCBI) - NCBI Bookshelf

What does finasteride do to DHT?

Finasteride inhibits the enzyme 5-alpha-reductase, which converts testosterone into DHT. This lowers the amount of DHT. With topical use this happens mainly in the scalp, with a smaller change in the blood than with the pill.

Source: 5-alpha-reductase inhibitors, StatPearls (NCBI) - NCBI Bookshelf

What is known about finasteride for hair loss?

The oral form (the pill) has long been researched for hereditary hair loss in men, with long-running studies over several years. The literature describes that it can prevent further hair loss in some men. What is suitable and to be expected for you is something you discuss with the doctor.

Sources: review article finasteride - PubMed 9951956 · long-term 5-year study - PubMed 11809594

What is topical finasteride and what does the study say?

Topical finasteride is applied to the scalp instead of swallowed. The core comes from a randomised study of 458 men that compared topical with the pill and with placebo. Click through for the design and the outcomes.

Source: Piraccini et al. (Topical Finasteride Study Group), JEADV 2022 - PubMed 34634163

How was the study set up?

Participants were randomly assigned to topical finasteride, the pill or placebo. Measurements covered hair growth in a fixed counting area, the amount of active ingredient in the blood and the drop in DHT in the blood. Randomisation and a placebo group make the comparison more reliable than individual user experiences.

What were the key outcomes?

Three things stood out. Click each point open for the number behind it.

Hair growth

Topical finasteride gave an increase of 20.2 hairs in the measurement area, versus 6,7 with placebo. The pill gave a similar result to topical.

Active ingredient in the blood

The maximum amount of active ingredient in the blood with topical was more than 100 times lower than with the pill.

Drop in DHT in the blood

DHT in the blood dropped by 34.5 percent with topical, versus 55.6 percent with the pill. Less change in the blood, while the effect on the scalp remained comparable.

Source: Piraccini et al., JEADV 2022;36(2):286-294 - PubMed 34634163

Topical or the pill, what's the difference?
Do they work the same way?

Both tackle hair loss in the same way. The difference is where the medicine ends up in your body. Click open the two forms.

The pill, you swallow it

Through your blood it reaches your whole body, including where it isn't needed.

Topical, on your head

You apply a few drops to your scalp. It mostly stays where you need it and much less ends up in your blood than with the pill.

Source: Piraccini et al., JEADV 2022 - PubMed 34634163

Does topical give the same result on hair growth?

In the comparative study the result on hair growth was similar: topical gave an increase of 20.2 hairs in the measurement area versus 6.7 with placebo, and the pill gave a similar result to topical. Results vary per person.

Source: Piraccini et al., JEADV 2022 - PubMed 34634163

Why does "in the blood" matter?

With the pill, the active ingredient travels through your blood to your whole body. Topical mostly stays where you need it, so much less ends up in your blood. Research looks at, among other things, whether that lower amount in the blood makes a difference. What that means for you is something you discuss with the doctor.

Source: Piraccini et al., JEADV 2022 - PubMed 34634163

Compounded and unregistered medicines
What does "compounded" mean?

Compounded means a pharmacy makes the treatment to measure for the patient, based on a prescription, instead of a ready-made factory product. This is a normal and regulated practice within Dutch pharmacy care.

What does "off-label" or "unregistered" mean?

The term refers to a medicine used outside the conditions of its official registration, or one that has no registration for a specific use. That may sound unusual, but it is a well-known and common practice in healthcare and does not in itself mean a medicine is unsafe or experimental.

Why is that done?

Before a medicine is registered, it goes through clinical research into safety and effectiveness for a certain use. During that research it sometimes emerges that a substance can also help with another use. A doctor can then prescribe a medicine for that other use when, in their judgement, it is in the patient's interest.

Does that also apply to minoxidil and finasteride?

Some individual formulas or combinations that are compounded to measure have no registration of their own for hair loss. That's often because a registration process is expensive and time-consuming and isn't always carried out for compounded uses. The active ingredients themselves have long been researched and used.

Why does Kádeso Labs choose topical preparations?

With a topical preparation, the active ingredient is applied directly to the scalp, where it is needed. Research into topical finasteride shows that much less active ingredient ends up in the blood than with the pill. Whether and to what extent that makes a difference for you is a medical decision the doctor makes with you.

Source: Piraccini et al., JEADV 2022 - PubMed 34634163

Who prepares my treatment?

The treatment is compounded to measure by Transvaal Apotheek in the Netherlands and delivered discreetly to your home.

Safety, side effects and expectations
What is known about side effects?

Like any medicine, finasteride and minoxidil can cause side effects. Part of the research into topical use looks at whether a lower amount of active ingredient in the blood makes a difference. What applies to you depends on your situation and is something you discuss with the doctor; general explanations on this page don't replace that conversation.

Source: Piraccini et al., JEADV 2022 - PubMed 34634163

Why can a topical form be different?

A topical form works mainly locally on the scalp, while a pill or tablet works throughout the whole body via the blood. Research compares these routes on things like how much active ingredient ends up in the blood. With topical minoxidil, local reactions such as itching or irritation occur; slightly more often at higher concentrations.

Sources: Olsen et al., J Am Acad Dermatol 2002 - PubMed 12196747 · oral versus topical minoxidil, JAMA Dermatol 2024 - PubMed 38598226

How long before you notice anything?

Hair grows slowly. Research usually measures over three to six months before a change becomes visible, and the effect only lasts with continued use. Temporary shedding can occur in the first weeks; the literature describes this as normal. What you can expect yourself is something you discuss with your doctor.

The doctor and the prescription
How do I get a prescription?

Fully online, in four steps. You don't need to leave the house and you don't need to make an appointment. Click the steps open.

Step 1, the online hair check

In about three minutes you answer a number of questions about your hair, your health and the medicines you use. This is the medical intake and also the only route to a treatment. You can do it whenever it suits you, including in the evening or at the weekend.

Step 2, personal review by the doctor

Je antwoorden gaan naar Prof. dr. Sherief Janmohamed, dermatoloog en professor. Hij bekijkt elk dossier zelf en bepaalt of een medisch begeleide behandeling in jouw situatie passend is. Dit is geen automatische goedkeuring en geen algoritme, maar het oordeel van een arts die haar en hoofdhuid als specialisme heeft.

Step 3, the prescription goes to the pharmacy

If the doctor finds a treatment suitable, he writes a prescription in your name and it goes to Transvaal Apotheek in the Netherlands. You don't need to collect a prescription, take anything to a counter or call anyone.

Step 4, prepared and delivered to your home

The pharmacy makes your treatment to measure and sends it discreetly to your home. We deliver in fixed rounds, twice a month. After that the support continues and you don't need to arrange anything again each quarter.

Who is the doctor and can I check that?

Your request is reviewed by Prof. dr. Sherief Janmohamed, dermatoloog en professor, BIG-nummer 39066055201. That number is public and personal, so you can check for yourself that he is qualified.

You can check it in the government's BIG register: search by BIG number. Enter 39066055201. Searching by number always gives the right person straight away; searching by name can cause confusion with people of the same name.

What is his background?

BIG-geregistreerd dermatoloog, professor aan het Universitair Ziekenhuis Brussel, gepromoveerd aan het Erasmus MC en postdoctoral fellow aan Northwestern University in de Verenigde Staten. Hij spreekt regelmatig in landelijke media over haaruitval en behandelingen.

What does BIG registration mean?

The BIG register is the government's legal, public register of healthcare providers who are allowed to practise their profession in the Netherlands. Anyone listed may use the title of doctor and falls under Dutch medical disciplinary law. Anyone can consult the register for free.

Why not just go through my GP?

You can of course, and your GP is always a good first point of contact. In practice, though, men with hair loss run into a few things.

Hair loss is a specialty, not a standard question

A GP is a generalist and sees hereditary hair loss relatively rarely. It's also not a condition that is medically urgent, so it often isn't dealt with first. If you want to see a specialist, there's usually a referral and a waiting time. At Kádeso Labs, a dermatologist looks at your request right away.

No appointment, no waiting room

No calling around the practice, no taking a day off, no waiting room and no conversation where you have to explain why you're there. You fill in the hair check at your own moment and the rest happens digitally. What we don't automate is the review itself: the doctor does that personally.

Compounded to measure instead of standard

Your treatment is prepared for you on prescription by Transvaal Apotheek, instead of taken off the shelf as a ready-made product. And the support doesn't stop at delivery: you hear from us throughout the year and there is a re-review.

How quickly will I know if I'm eligible?

The hair check takes about three minutes. Then the doctor reviews your file and you get a message by email. If a treatment is suitable, you join the next delivery round. If that's full, the round after follows, about two weeks later.

Can I speak to the doctor or his team?

Yes. The medical team calls you personally if there's something in your file that needs follow-up, and you can also contact us yourself with questions about your treatment. Digital doesn't mean there's nobody on the other side.

What if the doctor doesn't find a treatment suitable?

Then you get a message with the reason and you don't pay anything for a treatment. That happens, for example, with certain conditions or medicines, or when your complaints need further investigation first. So a rejection isn't a formality we work around; it's exactly what the review is for.

Review and registration
Is topical finasteride registered in the Netherlands?

No. Topical finasteride is not registered by the CBG or the EMA for hair loss. It is compounded to measure and supplied exclusively through a Dutch doctor and pharmacy, for adults. We state this fact deliberately and consistently.

Is my request really reviewed by a doctor?

Ja. Elke aanvraag wordt persoonlijk beoordeeld door dermatoloog en professor Prof. dr. Sherief Janmohamed. Hij bepaalt of een medisch begeleide behandeling passend is. Zo niet, dan krijg je bericht en betaal je niets voor een behandeling.

Sources (PubMed)

Piraccini BM e.a. (Topical Finasteride Study Group). "Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial." JEADV 2022;36(2):286-294. - PubMed 34634163

Messenger AG, Rundegren J. "Minoxidil: mechanisms of action on hair growth." Br J Dermatol 2004;150(2):186-194. - PubMed 14996087

Olsen EA e.a. "A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men." J Am Acad Dermatol 2002;47(3):377-385. - PubMed 12196747

"Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia: A Randomized Clinical Trial." JAMA Dermatol 2024. - PubMed 38598226

McClellan KJ, Markham A. "Finasteride: a review of its use in male pattern hair loss." Drugs 1999;57(1):111-126. - PubMed 9951956

"Long-term (5-year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia." - PubMed 11809594

"5-Alpha-Reductase Inhibitors." StatPearls, NCBI Bookshelf. - NCBI Bookshelf

BIG register (CIBG, Dutch Ministry of Health, Welfare and Sport). Look up a healthcare provider by BIG number. - zoeken.bigregister.nl

Please note: this is explanation, not medical advice. Results vary per person. Topical finasteride is not registered by the CBG or EMA for hair loss and is supplied exclusively through a Dutch doctor and pharmacy, for adults. In doubt? Ask your doctor.